Microscopic Animal PET/CT MadicLab PSA PET/CT
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Small animal PET/CT is a leading technology in the fields of basic medicine, bioengineering and medicine. It obtains various data on the physical condition of the animal and the distribution of drugs in the small animal by performing functional and anatomical imaging of rodents (mice or rats) in vivo. It can provide advanced technical support for tumors, neurological, cardiovascular diseases, genetic research, preclinical drug screening, etc. With the development of genomics, small animals are becoming increasingly important in modern molecular biology experiments. The emergence of "microscopic" small animal PET/CT has become an important tool for molecular imaging, which can clearly image the tiny details in the organs of mice.
"Microscopic" PET technology
The most commonly used animal model in medicine and pharmacy is the mouse model. In a paper published in the journal JNM, the team of Professor Simon R. Cherry of UC Davis proposed that "clear PET imaging of mice requires a spatial resolution of 0.5mm" [We call small animal PET with a spatial resolution of 0.5mm "microscopic" small animal PET.
Note: "A spatial resolution of ~0.5 mm is required for a small-animal PETscanner if one wants to image the mouse with the same relative spatial resolution as achieved in a human using a clinical whole body PETscanner with 5-mm spatial resolution (5,6)".[Literature source: JNucl Med.2016July; 57(7):1130-1135.]
Medwin's small animal PET uses a self-developed submillimeter PET probe with a spatial resolution of 0.48mm, ushering in an era of clear PET imaging for mice.
Compared with other molecular imaging methods, it has the following advantages:
► Basic research - clinical application - product transformation, seamless connection, isotope labeling of drugs, research on drug metabolism and biodistribution at the in vivo level, while the experimental results can be directly extrapolated to human research and verified by clinical PET, which can shorten the time for new compounds to enter clinical research, accelerate transformation and new drug launch, especially small molecule drugs.
► High sensitivity, capable of measuring picomolar to femtomolar drug concentrations in tissues of interest.
►Quantitative imaging can dynamically obtain kinetic data on the order of seconds, enabling rapid imaging of physiological and pharmacological processes.
►Non-invasive imaging, the injection dose is at the nanogram level, it will not produce pharmacological side effects, it is safe, reliable, convenient and easy.
►Intuitive and accurate, the use of rodent PET can significantly reduce experimental costs, and can be repeated on the same animal, continuous experiments, and self-control, avoiding species differences and intra-group differences.Principle: Use positron nuclides to label specific molecules, and obtain the distribution of molecules by measuring the distribution of positrons.
MadicLab PSA series products use "microscopic" PET technology and have passed the authoritative NEMA standard test. Among the six core parameters of the NEMA standard, five are internationally leading. These unique capabilities allow every researcher to conduct non-invasive research at the molecular level and explore more technological frontiers.
Features
►The smallest crystal cutting in the industry, with a spatial resolution of up to 0.48mm;
► Completely independent intellectual property rights, independent production of core components, and personalized configuration;
► Modular combination system, can directly upgrade high-precision detectors, products will never be outdated;
►Completely based on domestic R&D and production, delivery, technical support and after-sales service are timely and guaranteed;
►High-quality medical-grade CBCT, spatial resolution ≤50μm.Application Areas
1. Application of small animal PET - new drug development:
In vivo determination of biodistribution and pharmacokinetics of PET drugs in animals
Estimation of in vivo absorbed dose and preclinical radiopharmacological activity
Probe screening and identification
2. Application of small animal PET - tumor research:
Quantitative and dynamic monitoring of the distribution, metabolism, absorption and excretion of anticancer drugs in vivo
Efficacy evaluation, i.e. monitoring drug targets and efficacy, and evaluating drug treatment effects through pre- and post-treatment scans
Development of specific tumor probes
3. Application of Small Animal PET - Nervous System:
Able to clearly identify the structures in the animal brain, such as the thalamus, striatum, cortical substructures, etc.
Brain metabolic imaging uses 18F-FDG to measure the glucose metabolism rate in brain tissue and can diagnose Alzheimer's disease, Parkinson's disease, and epilepsy.
Brain amino acid metabolism imaging mainly reflects the level of protein synthesis and metabolism in the brain
4. Application of Small Animal PET - Cardiovascular:
Perform imaging of myocardial perfusion, metabolism, neural receptors, and genes to effectively reflect cardiac physiological and pathological changes and monitor myocardial stem cell transplantation
Atherosclerosis Research
5. Application of small animal PET - genetic research:
Gene imaging is the most effective method for quantitative monitoring of the localization and expression of transfected genesPET can image the distribution of gene vectors in vivo and can continuously and quantitatively monitor the location, abundance and expression time of gene expression.
Commonly used probes include: enzyme mediators and receptor mediators
Reference：
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