Cardiac electrophysiology matrix multi-channel mapping system Mappinglab
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- Product Description
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The cardiac electrophysiology multi-channel mapping system is the newest cardiac electrophysiology technology in the world.
* The device can be used for multi-channel cardiac electrophysiological mapping and can simultaneously monitor various cardiac function parameters.
* It can be used for electrical conduction mapping of in vivo heart, isolated heart, atrial tissue, ventricular tissue, sinoatrial node, atrioventricular node and other cardiac conduction tissues. It can monitor a variety of electrical conduction information, including: action potential pacemaker, conduction direction, conduction velocity, conduction mode, electrical conduction dispersion, repolarization dispersion, QT interval and dispersion.
* The device has 6 additional channels that can be used to simultaneously monitor ventricular systolic pressure, coronary artery perfusion pressure, unidirectional action potential, myocardial stretch, perfusion temperature and other information.
Compared with traditional recording methods, multi-channel cardiac electrophysiological mapping systems have many advantages: they do not cause mechanical damage to the surface of the heart, and the microelectrodes are directly attached to the myocardial cells on the epicardial surface, which can more faithfully record the electrophysiological activities of the myocardial cells at the contact site of the matrix electrode; they can non-damagefully map multiple adjacent extracellular sites synchronously and for a long time, and obtain a large amount of data, which provides convenience for researchers' research.
The system is simple to install and easy to operate. It can be installed on a test bench of 1 to 2 square meters and does not require commonly used electrophysiological supporting facilities such as anti-vibration tables and shielding nets.
Product Application:
Research on new drugs, evaluate their effects on various cardiac parameters, and assess their cardiotoxicity;
Antiarrhythmic studies, for atrial fibrillation, ventricular fibrillation, impulse conduction or origin abnormalities, etc.
Used for monitoring the effects of antiarrhythmic drugs and screening antiarrhythmic drugs.
Technical parameters:
1) The number of channels is 64, and the sampling rate of a single channel can reach 10KHz;
2) Input range: ± 100mV;
3) Magnification: 100 to 10000;
4) Recording bandwidth: DC to 5kHz;
5) Filtering: High-pass and low-pass filtering are continuously adjustable and can be easily adjusted in the software;
6) Analog-to-digital conversion 16 bits;
7) Voltage stimulation, ±10V, accuracy 1mV;
8) Provides a 5V level output interface, which can be used in the software to trigger a stimulator or other signal recording equipment;
9) Real-time video recording is possible, and the software can simultaneously record the electrode placement and specimen status.
10) The electrodes can be used for electrical signal mapping of cells, in vivo and isolated cardiac tissues.
References:
Huang Z, Chen XJ, Qian C, Dong Q, Ding D, Wu QF, Li J, Wang HF, Li WH, Xie Q, Cheng X, Zhao N, Du YM, Liao YH. Signal Transducer and Activator of Transcription 3/MicroRNA-21 Feedback Loop Contributes to Atrial Fibrillation by Promoting Atrial Fibrosis in a Rat Sterile Pericarditis Model. Circ Arrhythm Electrophysiol. 2016 Jul;9(7). pii: e003396. doi: 10.1161/CIRCEP.115.003396.
Atkinson AJ, Logantha SJ, Hao G, Yanni J, Anderson RH, Boyett MR, Dobrzynski, H. Functional, anatomical, and molecular investigation of the cardiac conduction system and arrhythmogenic atrioventricular ring tissue in the rat heart. J Am Heart Assoc. 2013 Dec 19;2(6):e000246. doi: 10.1161/JAHA.113.000246
Zi M, Kimura TE, Liu W, Jin J, Higham J, Kharche S, Hao G, Shi Y, Shen W, Prehar S, Mironov A, Neyses L, Bierhuizen MF, Boyett MR, Zhang H, Lei M, Cartwright EJ, Wang X. Mitogen-activated protein kinase kinase 4 deficiency in cardiomyo- cytes causes connexin 43 reduction and couples hypertrophy signals to ventricular arrhythmogenesis. J Biol Chem. 2011;286:17821-17830
Davies, L., Jin, J., Shen, W., Shi, Y., Wang, Y., Zhang, Y., Hao G, Wu, J., Chen, S., Fraser, J., Dong, N., Christoffels, V., Ravens, U., Huang, C., Zhang, H., Cartwright, E., Wang, X., Lei, M. (2013) MKK4 is a negative regulator of theTGF-β1 signaling associated with atrialremodelling and arrhythmogenesis with age. J Am Heart Assoc. 2014 Apr 10;3(2):e000340. doi: 10.1161/JAHA.113.000340User list:
Hebei Yiling Pharmaceutical Academician Workstation
The First Affiliated Hospital of Dalian Medical University
Union Hospital Affiliated to Huazhong University of Science and Technology
Stanford University Cardiovascular Institute
Department of Life Sciences, University of Cambridge, UK
Department of Pharmacy, University of Oxford, UK
Department of Physiology, University of Oxford, UK
Department of Medicine, University of Manchester, United Kingdom
Department of Life Sciences, University of Manchester, UK
Department of Biophysics, University of Manchester, UK
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