Inhalation Tower Exposure System
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- Product Description
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EMMS offers a complete solution for nose-only exposure applications with our inhalation exposure systems. We can provide the exposure tower, animal tubes, sensors, amplifiers and software. We are also able to provide a variety of different animal tubes to fit your existing exposure tower
1. Comprehensive animal modeling, precise quantitative inhalation drug administration, and toxic exposure solutions
2. Flexible and diverse aerosol generation and transmission methods (matched with different aerosol generators)
3. Real-time respiratory index monitoring
4. Economical and easy detection of aerosol particle concentration
5. Aluminum structure, strong and reliable
6. Standard configuration suitable for mice, rats, and guinea pigs
7. Various third-party external devices
8. Flexible modular design for different needs
9. Suitable for precise inhalation of liquid medicine atomization, dry powder particles, smoke, hydrocarbon vapor and high-value and expensive substances
10. Detecting the respiratory parameters of animals can accurately and quantitatively analyze the actual amount of drug inhaled
11. The software displays the aerosol concentration value in real time
12. Anti-corrosion, can be cleaned with alcohol and other disinfectants, and can also be sterilized by high pressure;
13. Oral and nasal inhalation devices for large animals such as rabbits, cats, dogs, pigs, monkeys, birds, and horses can be customized;
14. Optional aerosol particle diameter detection; total particle count detection cascade impactors condensation particle counters, etc.
Product Application:
This device of EMMS can be connected to various gas such as mist, dust, smoke, toxic gas, etc.The sol device is used for drug administration and oral and nasal exposure. The HOP recorder can detect the main respiratory function indicators of animals during exposure, and has the function of accurately measuring the drug or aerosol intake of each animal. The EMMS "TPM 100" aerosol concentration sensor uses an 880nm grating, which can play an important role in monitoring the actual inhalation amount of animals. This equipment is suitable for accurate inhalation modeling of animals such as COPD and asthma, toxicology and safety evaluation of various chemicals and drugs, and efficacy analysis research.
Schematic diagram of a typical configuration with aerosol concentration detection and animal respiratory function detection
Technical parameters:
Main Application: To evenly distribute various inhalation media for animal oral and nasal inhalation modeling or quantitative administration
Applicable animals: mice and rats
The number of animals that can be accommodated ranges from 10 to 48.
Air supply system flow adjustment range 0~12LPM
Air supply steady flow regulation with pressure flow balancing device to control ventilation dynamic changes
Allowed input media types: aerosol, smoke, dust, various special gases
The working environment has exhaust gas filtration function and can be placed in an ordinary workbench, fume hood, or biosafety cabinet.
The working mode allows working under both positive pressure and negative pressure
The main structure of the inhalation tower has a double-layer shell "DirectFlow" design inside and outside, with guided horizontal air intake and exhaled air discharged into the inner cavity to avoid repeated inhalation; and it can ensure that the air intake volume of the inhalation chambers of animals at different positions and levels is consistent.
Low dead space design allows low ventilation flow exposure to save drug use costs
The "DirectFlow" design of the double-layer shell inside and outside the laminar air intake ensures that the air intake is a smooth laminar flow and does not generate vortex turbulence that causes aerosol particles to collide and combine into large particles.
The air inlet and outlet directions can be switched to two modes: top air inlet and bottom exhaust, or bottom air inlet and top exhaust.
Quantitative inhalation TPM quantitatively detects aerosol concentration to determine the effective inhalation volume of animals
Aerosol concentration measurement method: TPM infrared spectrophotoelectric sensor (wavelength 880nm)
Aerosol concentration measurement range 0.001~2500 mg/m3 (standard medium is Arizona Road Dust)
Aerosol concentration measurement resolution 0.001 mg/m3
Filter calibration with multi-layer filter set for physical measurement of aerosol throughput
Respirable particle size distribution ratio test uses Cascade Impactor to measure the deposition of particles of different sizes
Atomization time controller 0~99min
Atomizing medium: non-flammable volatile mixed solution (no visible suspended matter)
Atomized particle diameter 2.5~4um, 4~6um
Nebulization volume 5ul~10ml
Atomization rate adjustment range 5%~100%
With smoke pump interface, it can be connected to cigarette smoke generator, haze particle dust generator, toxic gas generator
Animal containers allow for both nose-only and head-out Plethysmograph animal cavities
Nose-only restrainers are used for exposure to inhalation, and the animal body is exposed to facilitate various operations such as tail vein testing.
Head-out Plethysmograph can be connected to a lung function system to detect respiratory parameters during animal cavity exposure and inhalation (upgrade option)
Can it be cleaned and disinfected? The detachable modular design makes it easy to clean the internal pipes and allows alcohol, ultraviolet light, and special gas fumigation disinfection.
Material: Aluminum
Client List:
Shanghai Public Health Clinical Center, School of Medicine, Fudan University, Shanghai
Shenzhen East Sunshine Pharmaceutical Group Research Institute
Department of Physiology, Capital Medical University
Academy of Military Medical Sciences
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