The fully automatic blood collection instrument system can improve the automation level of preclinical animal experiments and improve the quality of data. It does not add extra tension and stress to animals like traditional methods, thus making the data of drug metabolism and kinetics more reliable. Under the premise of ensuring data quality, the use of CulexâABC can greatly reduce the number of experimental animals, and at the same time, different types of data can be collected from the same group of experimental animals, such as system dynamics, pharmacodynamics, and animal behavior monitoring data, etc. CulexâABC reduces the average labor required for animal experiments and replaces the traditional method of manual recording with computer automation, greatly reducing the manpower, material resources and time costs of the laboratory.

Simple and compact system size (~81cm x 41cm x 48cm)

Collect blood samples, can be upgraded to collect other samples

Best suited for small animals and small sample sizes, no impact on the animal’s health

Can meet the automatic collection requirements of rats and mice at the same time

Sampling volume from 5μL - 1mL (upgradable)

Sampling can be carried out at any time of day or night, ranging from rodents such as mice to large animals (different models),

Upgradeable animal physiological parameter monitoring, available to include temperature probes, ECG leads and implantable blood pressure sensors.

The sampling tube is disposable and sterile, and is compatible with other blood collection consumables. The flushing procedures allow the cannula to be reused, and the sample collector is stored in a freezer (4°C).

The experimental installation is completed within 10 minutes, easy to clean, and the blood collection time is 3-5 minutes.

Animal health status: The animal is conscious and in a free-moving state. The software displays the total blood volume sampled and helps you maintain IACUC standards. The saline automatically compensates for the drawn blood. The unique "TEND" function ensures that the entire pipeline is unobstructed.

Little or no manual operation reduces stress on animals and technicians. The software is easy to use and can control up to 4 animals from one computer. Automatically generates reports for perfusion and sampling equipment.

Equipped with automatic alarm processing software for missed mining to reduce missed mining

Upgradeable to include large animals like pigs and primates.

Size (~55cm x 41cm x 44cm)

Sturdy, durable and easy to carry

The Culexâ fully automated blood collection system is a new automated system for studying preclinical drug metabolism, pharmacokinetics and pharmacodynamics. It is a technology for conducting animal research between drug discovery and clinical trials.

Technical parameters:

　　1、 集小动物自动采血给药多种功能为一体，可升级，各功能可以独立操作。
　　2、采血技术原理：采样时采取独立控制装置，通道截止阀保证血液在导管移动中，不被生理盐水稀释，按实验要求采集相应的样本。
　　3、使用注射泵驱动，非常精确，保证±5%的精确度，实际采样中精确度通常在±2%，不用校准。
　　4、采血样本量范围：为保证不同大小动物实验要求，最低采血量≥5ul，最大采血量≤1000ul
　　5、采血周期：一般小于5分钟(视实验情况而定，最长不超过10分钟)
　　6、为满足收集器的便携性，采集样本位26或48个，带冷藏装置，恒温在4℃下保存样品
　　7、操作方便，安装快捷，无易损部件。
　　8、生理盐水补充，根据采样量自动、准确用生理盐水补充动物损失的血液，保证动物处于健康状态，TEND功能保证管路的畅通。
　　9、带有光学感应，自动检测异常，侦测漏采、异常并自动重采的功能，具备漏采自动报警处理软件，能减少漏采现象。
　　10、软件，显示取样的总血量，符合IACUC标准，自动生成灌注和取样报告。一台电脑可以同时控制4套设备同时实验。
　　11、简单的紧凑的系统大小(~81cm x 41cm x 48cm)
　　12、配置灵活，可与其他设备同时联机使用，最大程度满足实验需求，可同时在一只动物体进行采血(或给药)和微透析取样、胆汁采集等。可以升级代谢笼，收集动物的尿液和粪便，做药代动力学及药物代谢等方面的研究。
13、可升级性：配合遥测装置--测量动物生理参数，可以实现采血过程中实时监测动物的血压，体温，心电等生理参数。
1. It integrates multiple functions of automatic blood collection and medication for small animals, is upgradeable, and each function can be operated independently.
2. Principle of blood collection technology: An independent control device is used for sampling, and the channel shut-off valve ensures that the blood is not diluted by saline during the movement of the catheter, and the corresponding samples are collected according to the experimental requirements.
3. Driven by a syringe pump, it is very precise and guarantees an accuracy of ±5%. In actual sampling, the accuracy is usually ±2% and no calibration is required.
4. Blood sample volume range: To ensure the experimental requirements of animals of different sizes, the minimum blood volume is ≥5ul and the maximum blood volume is ≤1000ul
5. Blood collection cycle: generally less than 5 minutes (depending on the experimental situation, the longest time is no more than 10 minutes)
6. To meet the portability of the collector, there are 26 or 48 sample collection positions, equipped with a refrigeration device to store samples at a constant temperature of 4°C
7. Easy to operate, quick to install, and no vulnerable parts.
8. Physiological saline supplement: automatically and accurately supplement the animal's lost blood with physiological saline according to the sampling volume to ensure that the animal is in a healthy state. The TEND function ensures the smooth flow of the pipeline.
9. It has the functions of optical sensing, automatic detection of abnormalities, detection of missed sampling, abnormalities and automatic re-sampling, and automatic alarm processing software for missed sampling, which can reduce the phenomenon of missed sampling.
10. Software, displays the total blood volume sampled, meets IACUC standards, and automatically generates perfusion and sampling reports. One computer can control 4 sets of equipment for simultaneous experiments.
11. Simple and compact system size (~81cm x 41cm x 48cm)
12. Flexible configuration, can be used online with other equipment to meet the experimental needs to the greatest extent, can simultaneously perform blood sampling (or drug administration) and microdialysis sampling, bile collection, etc. on an animal. Metabolic cages can be upgraded to collect urine and feces of animals for research on pharmacokinetics and drug metabolism.
13. Upgradability: With the telemetry device to measure the physiological parameters of animals, it is possible to monitor the animal's blood pressure, body temperature, ECG and other physiological parameters in real time during the blood collection process.

References:

1. Liquid chromatography/tandem mass spectrometry for the determination of carbamazepine and its main metabolite in rat plasma utilizing an automated blood …2.967
Determination of carbamazepine and its major metabolites in rat plasma using liquid chromatography-tandem mass spectrometry and automated blood sampling system
Y Zhu, H Chiang, M Wulster-Radcliffe, R Hilt… - … of pharmaceutical and …, 2005 - Elsevier ... The capillary temperature was set at 275 °C. 2.3. Automated blood sampling system.
The blood collecting system consisted of a robotic automated blood sampler (Culex™, BASi), and a freely moving rat containment device (Raturn, BASi). ...
2. [PDF] Determination of naringenin in rat plasma with the Culex® automated blood sampler coupled with liquid chromatography/electrochemistry hktmc.com [PDF]
Automatic blood sampling/electrochemical citrus extract rat plasma
F Xie, M Wulster-Radcliffe, R Hilt… - Asian J Drug Metab…, 2004 - hktmc.com ... Determination of naringenin in rat plasma with the Culex® automated blood ... Apparatus and analytical conditions Determination of NG-E by LCEC was performed on a BAS 200B LCEC system equipped with a low dead volume micro-injector (10 µL loop, BASi, West Lafayette, IN ...
3. [HTML] A comparative study of the pharmacokinetics of traditional and automated dosing/blood sampling systems using gabapentin 0.727
[HTML] from nih.gov
Comparative study of the pharmacokinetics of gabapentin using conventional and automated dosing/blood sampling systems
B Aryal, K Tae-Hyun, K Yoon-Gyoon… - Indian Journal of…, 2011 - ncbi.nlm.nih.gov… Apparatus and Conditions The automated blood sampling unit [Figure 2a] consisted of a freely moving rat containment device (RaturnTM, BASi, West Lafayette, IN) and an automated blood sampler Culex™ (BASi). The blood..
4. [HTML] Pharmacokinetics of venlafaxine and its major metabolite o-desmethylvenlafaxine in freely moving mice using automated dosing/sampling system 0.727
[HTML] from nih.gov
Pharmacokinetics of venlafaxine and its major metabolite desvenlafaxine in freely moving mice using an automated perfusion/acquisition system
B Aryal, D Aryal, EJ Kim… - Indian Journal of …, 2012 - ncbi.nlm.nih.gov ... All other chemicals used were of analytical grade. Apparatus and Conditions The automated blood sampling consisted of a freely moving mouse containment device Raturn™ (BASi, West Lafayette, IN, USA), and an automated blood sampler Culex ™ (BASi)...

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