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Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways

Li Z, Ran Q, Qu C, Hu S, Cui S, Zhou Y, Shen B, Yang B. Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways. Biol Direct. 2025 Feb 25;20(1):23. doi: 10.1186/s13062-025-00617-y.

Biomedical application of TiO2NPs can cause arterial thrombotic risks through triggering procoagulant activity, activation and aggregation of platelets

Bian Y, Jin Q, He J, Ngo T, Bae ON, Xing L, Pi J, Chung HY, Xu Y. Biomedical application of TiO2NPs can cause arterial thrombotic risks through triggering procoagulant activity, activation and aggregation of platelets. Cell Biol Toxicol. 2024 Aug 7;40(1):67. doi: 10.1007/s10565-024-09908-y.

CARD9 protein SUMOylation regulates HOXB5 nuclear translocation and Parkin‐mediated mitophagy in myocardial I/R injury

Li Y, Tang Y, Yan X, Lin H, Jiang W, Zhang L, Zhao H, Chen Z. CARD9 protein SUMOylation regulates HOXB5 nuclear translocation and Parkin-mediated mitophagy in myocardial I/R injury. J Cell Mol Med. 2024 Nov;28(21):e70195. doi: 10.1111/jcmm.70195.

Leptin drives glucose metabolism to promote cardiac protection via OPA1-mediated HDAC5 translocation and Glut4 transcription

Yang F, He Y, Zhao L, Huang J, Du F, Tian S, Zhang Y, Liu X, Chen B, Ge J, Jiang Z. Leptin drives glucose metabolism to promote cardiac protection via OPA1-mediated HDAC5 translocation and Glut4 transcription. Funct Integr Genomics. 2025 Jan 29;25(1):28. doi: 10.1007/s10142-024-01515-8.

Empagliflozin alleviates obesity-related cardiac dysfunction via the activation of SIRT3-mediated autophagosome formation

Luo Y, Ye T, Tian H, Song H, Kan C, Han F, Hou N, Sun X, Zhang J. Empagliflozin alleviates obesity-related cardiac dysfunction via the activation of SIRT3-mediated autophagosome formation. Lipids Health Dis. 2024 Sep 27;23(1):308. doi: 10.1186/s12944-024-02293-9.

Integrating bioinformatics and ferroptosis to reveal the protective mechanism of Astragaloside IV on chronic heart failure rats

Yuan H, Shi M, Wei J, Liu C, Wang Z, Li Y, Guo Z. Integrating bioinformatics and ferroptosis to reveal the protective mechanism of Astragaloside IV on chronic heart failure rats. Sci Rep. 2024 Sep 6;14(1):20787. doi: 10.1038/s41598-024-72011-z.