NVision POLARIS Hyperpolarized Magnetic Resonance System
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- Product Description
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NVision POLARIS is a revolutionary preclinical platform for hyperpolarized magnetic resonance imaging (HP-MRI) that enables real-time, non-invasive, and dynamic visualization of metabolic processes in living organisms. By utilizing hyperpolarization technology, it enhances the magnetic resonance signal of ¹³C-labeled molecules (such as [1-¹³C]pyruvate) by more than 10,000-fold, allowing researchers to observe intracellular metabolic activities as if "watching a live broadcast," thus overcoming the sensitivity limitations of conventional MRI in metabolic detection.
1. Enables real-time observation of metabolic processes in living organisms
2. Quantifiable and intuitive — combined with the advantage of spatial resolution
PHIP (Parahydrogen-Induced Polarization)
NVision's revolutionary approach. At room temperature and under low-to-medium magnetic fields, the spin polarization of parahydrogen is transferred to target metabolites via chemical reactions. The process is fast, efficient, and requires no extreme low temperatures.
With PHIP technology, POLARIS transforms hyperpolarization from a "high-threshold facility" into a "routine laboratory tool," achieving fundamental breakthroughs in speed, convenience, cost, and safety.
3. System Details: POLARIS – A Convenient, Efficient, and Reliable Solution
Overall DesignIntegrated compact design with built-in polarization module, gas lines, and control system. Modern appearance with a footprint of less than 0.5 m².
Four Core Advantagesa. Ultimate Convenience: Operates by simply connecting to a power source and standard gases (nitrogen, parahydrogen). From unboxing to producing the first sample takes only a few hours.
b. Reliable Efficiency: Utilizes standardized, pre-calibrated, ready-to-use kits. Stable polarization efficiency, high single-preparation success rate, and excellent experimental reproducibility.
c. Fast & High-Throughput: From sample loading to obtaining an injectable hyperpolarized solution takes only about 2–3 minutes. Capable of producing up to 4 samples per hour (including semi-automated cleaning time).
d. Cost-Effective: No expensive consumables such as liquid helium. Equipment procurement and long-term operating costs are significantly lower than DNP systems, offering a substantial Total Cost of Ownership (TCO) advantage.
4. Research Applications: Empowering Multidisciplinary Frontier Exploration
Tumor Metabolism & Treatment Response:Real-time monitoring of tumor glycolytic activity; assessing drug efficacy within hours to days after treatment initiation; early detection of drug resistance; guiding personalized therapy.
Cardiac Metabolism & Function:Non-invasive assessment of the energy metabolism status of cardiomyocytes; applied in early diagnosis and treatment efficacy monitoring of heart failure, myocardial ischemia, and other cardiac conditions.
Neuroscience & Brain Metabolism:Visualization of energy metabolism and neural activity in specific brain regions; applied in research on brain tumors, neurodegenerative diseases (e.g., Alzheimer's disease), stroke, and more.
Other Fields:Also holds great potential in studying metabolic reprogramming in liver diseases (e.g., NASH), kidney diseases, and inflammatory conditions (e.g., arthritis).
Oncology Research
Precise Diagnosis and Stratification: Taking prostate cancer as an example, by injecting hyperpolarized [1-¹³C]pyruvate, the process of its conversion to lactate can be tracked in real time. By analyzing the signal ratio of pyruvate to lactate, it is possible to effectively distinguish high-risk lesions (e.g., Gleason score ≥7) from normal tissue, providing a basis for early cancer diagnosis and risk stratification. Monitoring Treatment Response: During the development of new anticancer drugs or therapies, this technology can be used to conduct longitudinal studies in the same animal model before and after treatment. By observing changes in metabolite signals in the tumor region, researchers can quickly assess whether the drug has reversed aberrant metabolic patterns, thereby accelerating drug screening and development processes.
Cardiovascular Disease Research
Myocardial Metabolic Assessment: Non-invasively assess the energy metabolism patterns of the myocardium under different conditions such as health, ischemia, reperfusion injury, or heart failure. By tracking the metabolic flux of pyruvate in cardiomyocytes in real time, researchers can directly visualize whether the heart relies on aerobic respiration or anaerobic glycolysis for energy production.
Atherosclerotic Plaque Study: This technology can "see" the metabolic activity of plaques within the arterial wall. By analyzing the metabolic characteristics of plaque regions, it is possible to assess their stability and vulnerability, as well as dynamically monitor the impact of drug interventions on the metabolic microenvironment of plaques.
Neuroscience Research
Brain Function–Metabolism Coupling Studies: Enables real-time monitoring of changes in energy metabolism within brain regions associated with specific cognitive tasks. For example, by tracking metabolic activity in the visual cortex following visual stimulation, the relationship between neural activity and energy consumption can be directly revealed. Exploration of Neurological Disease Mechanisms: For complex neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, as well as acute conditions like stroke, this technology allows researchers to dynamically observe the disruption of metabolic networks in the brain during disease progression, thereby uncovering potential pathophysiological mechanisms. Brain Tumor and Ischemia Monitoring: In brain tumor research, the technology can non-invasively identify the abnormal "Warburg effect" within tumor regions. In stroke models, it can be used to monitor the metabolic recovery of ischemic regions in real time, providing critical information for timing thrombolytic therapy.
Practical Demonstration of the POLARIS Hyperpolarization Workflow
Key Related Publications
Chia ML, Bulat f, Gaunt A, Ros S, Wright AJ, Sawle A, Porcu L, Vias M, Brenton JD, Brindle KM. Metabolicimaging distinguishes ovarian cancer subtypes and detects their early and variable responses to treat.ment, Oncogene.2025 Mar;44(9):563-574.dol: 10.1038/s41388-024-03231-w.Epub 2024 Dec 6. PMID:39639170:PMCID:PMC11850285.
Timm KN, Perera c, Ball v, Henry JA, Miller JJ, Kerr M, West jA, Sharma E, Broxholme J, Logan A, Savic D,Dodd MS, Grifin JL, M urphy M P, Heather Lc, Tyler Dy. Early detection ofdoxorubicin-induced cardiotox-icity in rats by its card iac metabo lic signature assessed with hyperpolarized MRl.Commun Biol. 2020 Nov19:3(1):692, doi:101038/$42003-020-01440-2 PMID:33214680;PMCID:PMC7678845.
Qin H, Zhang v, Bok RA, SantosRD,Cunha JA, Hsu ic, Santos BsJD,Lee JE, Sukumar S,Larson PEZ, Vign.eron DB, Wilson DM, Sriram R, Kurhanewicz J. Simultaneous Metabolic and Perfusion lmaging UsingHyperpolarized 13C MRl Can Evaluate Early and Dose-Dependent Response to Radiation Therapy in aProstate Cancer Mouse Model, int 」 Radiat Oncol Biol Phys. 2020 Aug 1;107(5):887-896. dol:10.1016/jijrobp.2020.04.022.Epub2020 Apr25.PMID:32339646; PMCID: PMC7381368.
Guglielmetti C, Cordano C, Najac C, Green AJ, Chaumeil MM, lmaging immunomodulatory treatmentresponses in a multiple sclerosis mouse model using, hyperpolarized 13c metabolic MRl. Commun Med(Lond).2023 May 22;3(1:71,dol: 10.1038/43856-023-00300-1.PMID:37217574;PMCID:PMC10202949.
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