Laser Speckle Blood Flow Imager BFIO-HR
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- Product Description
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The laser speckle blood flow imager is designed with the emerging LSCI (laser speckle contrast imaging) technology. With its unique technical advantages of non-contact, high-resolution, and full-field rapid imaging, it provides a new and effective means of blood flow monitoring and blood flow imaging for clinical medicine and basic research in life sciences. The instrument does not require any contrast agent, and its time resolution can reach milliseconds and its spatial resolution can reach micrometers, which enables scientific researchers and medical personnel to observe the blood flow distribution state of microvessels and the relative changes of blood flow values in real time. The instrument can be used in the fields of basic research in life sciences, new drug development, and blood flow monitoring in multiple clinical departments.
1. Fast, full-field blood flow imaging with temporal resolution down to milliseconds and spatial resolution down to micrometers
2. No mechanical scanning, no contrast agent, non-contact imaging
3. Can conduct qualitative and quantitative analysis of changes in blood flow velocity
4. Using an algorithm that corrects static tissue structure interference and multiple scattering effects, the accuracy of quantitative analysis of blood flow velocity is significantly improved;
5. Highly coherent and stable laser light source and 12-bit low-noise fast camera ensure excellent long-term stability of flow velocity measurement;
6. Integrated color imaging illumination light source and blood flow imaging laser light source, automatic switching of dual filter channels can achieve zero interference between color imaging and blood flow imaging, greatly simplifying user operations;
7. Unique parallel image reconstruction algorithm realizes high-speed blood flow image reconstruction and flexible configuration of real-time data filtering;
8. It can conduct real-time online analysis and offline loading analysis of the average blood flow in the ROI, and supports the drawing, copying and deletion of any shape and number of ROIs. The position and size of the ROI can be adjusted freely by dragging and dropping;
9. Real-time online analysis and offline loading analysis of vascular diameter values can be performed, and any number of vascular diameters can be drawn, copied, and deleted.
10. It has the function of expanding the measurement of hemodynamic multi-parameters, realizing the simultaneous measurement of blood flow, blood oxygen and blood volume parameters;Changes of cerebral cortical blood flow during recovery from hypoxia in mice (intact skull)
Photochemically induced cerebral cortical vascular embolism model in mice
Mouse mesenteric blood flow imaging
Blood flow imaging in mouse skin window model
Mouse paw blood flow imaging
References:
1. Zou Tan, Jinde Zhang, Xiangyu Niu, Lisheng Lin, Buhong Li. Monitoring blood flow during vascular-targeted photodynamictherapy using laser speckle imaging. Asia Communications and Photonics Conference,2016
2. Jinde Zhang, Zou Tan, Xiangyu Niu, Linsheng Lin, Huiyun Lin, Buhong Li.Blood vessel damage correlated with irradiance for in vivovascular targeted photodynamic therapy. Proc. of SPIE Vol. 10024 100244N-2,2016
3. Zhiguo Li, Qin Huang, Peng Liu, Pengcheng Li, LiantingMa,Jinling Lu, Functional response of cerebral blood flow induced bysomatosensory stimulation in rats with subarachnoid hemorrhage, Journal of Biomedical Optics,2015, 20(9): 0960084. Min Zhe, Li Changsheng, Fang Yu, Qiu Zhandong, Zhang Suming, Application of laser speckle imaging technology in the observation of collateral circulation in rat middle cerebral artery occlusion model, Neural Injury and Functional Reconstruction, 2014, 9(3): 191-194. (Tongji Hospital Affiliated to Huazhong University of Science and Technology)
5. Min Zhe, Li Changsheng, Fang Yu, Qiu Zhandong, Zhang Suming, Application of laser speckle imaging technology in the observation of collateral circulation in rat middle cerebral artery occlusion model, Neural Injury and Functional Reconstruction, 2014, 9(3): 191-194. (Tongji Hospital Affiliated to Huazhong University of Science and Technology)
User list:
Chinese People's Liberation Army General Hospital
Union Hospital Affiliated to Huazhong University of Science and Technology
Tongji Hospital Affiliated to Huazhong University of Science and Technology
Guangzhou Military Region Wuhan General Hospital
The First Affiliated Hospital of Jinan University
Chengdu Military Region General Hospital
Wuhan First Hospital
Wuhan Third Hospital
Guangzhou University of Chinese Medicine
Fujian Normal University
Jinan Military Region General Hospital
Institute of Physics and Chemistry, Chinese Academy of Sciences
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