Yeeran is the first to launch the first portable small animal ultrasound device, which is a high-frequency and high-resolution small animal ultrasound imaging system developed specifically for experimental small animals, providing researchers with non-invasive continuous analysis, high-resolution image quality and quantitative analysis of tissue structure and blood flow velocity. Through hardware and software designed specifically for mice and rats, as well as optimized ergonomic operation design, it provides researchers with cost-effective application tools in cardiovascular research, gene expression pattern analysis, tumor research and drug development.

 

 

 

RF Metadata Platform Opens a New Era in Ultrasound Diagnosis

 

◆ High resolution
◆ Self-developed image processing algorithm based on lossless signal
◆ Multi-level calculation and scaling, closer to the real value
◆ The amount of signals processed by the backend is 40 times that of regular signals
◆ High Dynamic Range, HDR
◆ Non-linear demodulation
◆ Improve the display of fine details
◆ High contrast
◆ Clear boundaries

  

    

Layering of nails                                                      Slow blood flow 1mm below the skin

 

Main system

The main system uses Altera's FPGA chip. In the FPGA field, Altera occupies 41% of the market share and has always maintained its market and technology leadership. Its performance of large-scale system data makes the image subtle and guarantees the high performance and long life of the system.

 

  

 

 

French VERMON high frequency probe

Since 1984, VERMON has been committed to designing and manufacturing advanced and unique transducer technology. It is VERMON's strategy to provide customized products with innovative ultrasonic diagnostic modalities to customers around the world. Vermon has been a leader in piezoelectric composite technology.

 

 

   

RF Flow is full and does not overflow                         Xcen UHF Superficial Development

 

 

The quality of the probe mainly depends on the following components: acoustic lens, matching layer, transducer, backing material, cable. From material, design to manufacturing process, VINNO probes are impeccable.

◆  Upper material: composite piezoelectric ceramics and single crystal are used to improve image penetration. At the same time, advanced XTech technology can effectively increase the resolution by 20-40%.

◆ The higher the probe frequency, the thinner the piezoelectric crystal, the greater the possibility of damage. VINNO uses first-class piezoelectric materials and non-pin interface design to improve reliability and reduce damage.

◆ Compared with the traditional probe with 128 array elements, the VINNO ultra-wide probe can effectively expand the acquisition range of its 256 array elements. At the same time, the adaptive frequency is set to improve the image quality of different tissues and organs.

 

、、

 

Easy Compare Tracking

 

Real-time images                        Historical images

 

Micromagnetic navigation—precise positioning outside the body 

 

  Fixed-site tumor implantation                                                 Direct injection

 

Complete functional modules: Cardiac measurement package                            

 

 

 

Product Application:

 

Mouse long axis B type                                              Mouse short axis B

 

Mouse long axis M-type                                               Mouse long axis M-type

  

 

Mouse aortic arch blood flow                                                Mouse kidney

 

Mouse Mitral Valve Tissue Doppler                                              Mouse liver

 

 

 Rat fetal heart blood flow                                Rat apical four-chamber heart

 

 

 

Ultrasound Literature:

1.α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure Zhang, N., Zhang, Y., Xu, J. et al. α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure. Cell Res 33, 679–698 (2023).doi: 10.1038/s41422-023-00844-w.

2.BAF155 promotes cardiac hypertrophy and fibrosis through inhibition of WWP2-mediated PARP1 ubiquitination Zhang, N., Zhang, Y., Chen, Y. et al. BAF155 promotes cardiac hypertrophy and fibrosis through inhibition of WWP2-mediated PARP1 ubiquitination. Cell Discov 9, 46 (2023).
doi: 10.1038/s41421-023-00555-x.

3.Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction.Circulation. 2024 May 7;149(19):1516-1533.doi:10.1161/CIRCULATIONAHA.123.065390

4.Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo He, Y., Dong, XH., Zhu, Q. et al. Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo. Military Med Res 9, 9 (2022).doi: 10.1186/s40779-022-00369-0.
Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles Liu, S., Chen, X., Bao, L. et al. Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles. Nat Biomed Eng 4, 1063–1075 (2020).doi: 10.1038/s41551-020-00637-1

5.Construction of tissue-engineered vascular grafts with enhanced patency by integrating heparin, cell-adhesive peptide, and carbon monoxide nanogenerators into acellular blood vessels Construction of tissue-engineered vascular grafts with enhanced patency by integrating heparin, cell-adhesive peptide, and carbon monoxide nanogenerators into acellular blood vessels.Bioact Mater. 2024 Apr; 34: 221–236.doi: 10.1016/j.bioactmat.2023.12.015.

 

Partial user units (hospitals, universities, pharmaceutical companies and CRO companies):
Peking University
Shenzhen Hospital of Fuwai Hospital of Chinese Academy of Medical Sciences
School of Pharmacy of Tsinghua University
Harbin Medical University
The First Affiliated Hospital of Zhengzhou University
Tianjin TEDA International Cardiovascular Hospital
Inner Mongolia International Mongolian Medicine Hospital
School of Physical Education of Shaanxi Normal University
Affiliated Hospital of Qingdao University
The First Affiliated Hospital of Xi'an Jiaotong University
Shengjing Hospital of China Medical University
Central Laboratory of People's Hospital of Wuhan University
Air Force Medical University
Tianjin University of Traditional Chinese Medicine
Shaanxi Institute of Traditional Chinese Medicine
Henan University of Traditional Chinese Medicine
National Liver Cancer Center of Shanghai Oriental Hepatobiliary Hospital
Kunming Yan'an Hospital
Hunan University of Traditional Chinese Medicine
Southern Medical University
School of Life Sciences of University of Science and Technology of China
Cambridge Genome Resource Center of Soochow University
Animal Center of Zhejiang University of Traditional Chinese Medicine
Zhejiang University
Ruian People's Hospital
School of Pharmacy of Nanchang University
Medical Research Institute of Wuhan University
Gannan Medical College
Department of Experimental Animal Science of School of Medicine of Shanghai Jiaotong University
Affiliated Tongji Medical College of Huazhong University of Science and Technology Tongji Hospital
Novo Nordisk (China) Pharmaceutical Co., Ltd.
Shengjing Hospital Affiliated to China Medical University
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
The First Affiliated Hospital of Xi'an Jiaotong University
School of Basic Medicine of Qingdao University
China Medical University
Experimental Animal Center of Nanjing University Drum Tower Hospital
Third Military Medical University
Wonkwang University, South Korea
Experimental Animal Center of Nanchang University
Union Hospital Affiliated to Fujian Medical University
Cardiovascular Research Institute of Shanghai Changzheng Hospital
Innos Biotechnology Nantong Co., Ltd.
Kasai Biotechnology (Suzhou) Co., Ltd.
Shanghai Puling Biotechnology Co., Ltd.
Beijing Aisiyipu Biotechnology Co., Ltd.
Youji (Tianjin) Pharmaceutical Technology Co., Ltd.
Suzhou WuXi AppTec New Drug Development Co., Ltd.
Beijing Saifu Pharmaceutical Research Institute Co., Ltd.
Tibet University for Nationalities
Second Xiangya Hospital of Central South University
Chongqing Medical University
Guangdong-Hong Kong-Macao Central Nervous Regeneration Research Institute of Jinan University
Cardiovascular Research Institute of Kunming Yan'an Hospital
General Hospital of Shenyang Northern Theater Command