Application of Mapping Technology in Cardiac Electrophysiology Research
Release time:
2023-05-17
Title:Application of Mapping Technology in Cardiac Electrophysiology Research
Speaker：Dr. Guoliang Hao
Guest Introduction:
Dr. Guoliang Hao, received his PhD degree in biomedical sciences from the University of Manchester, UK in 2012, and was a postdoctoral fellow at the University of Oxford, UK from 2012 to 2018.
He is the founder of SCO Electrophysiology Research Institute and has established a cardiac electrophysiology research team with world priority advantages. He is currently a visiting researcher at the University of Oxford, Director of the Key Laboratory of Cardiac Electrophysiology in Henan Province, Director of the International Joint Laboratory of Cardiac Electrophysiology in Henan Province, Director of the Engineering Research Center for Preclinical Drug Safety Evaluation in Henan Province, Distinguished Professor of the Cardiac Center of the First Affiliated Hospital of Xinxiang Medical College, Member of the Chinese People's Political Consultative Conference (CPPCC) of Henan Province, and Member of the Specialized Committee on Toxicity Pathology of Chinese Toxicology Society.
His research interests include arrhythmia mechanism research, anti-arrhythmic drug screening, and preclinical cardiac safety evaluation. He has presided over the High-end Foreign Experts Program of the Ministry of Science and Technology of the People's Republic of China, the Central Government Guided Local Science and Technology Development Special Project, and the Provincial and Ministerial Key Research and Development Special Projects. He has published more than 30 SCI articles in European Heart Journal, Journal of Physiology, Hypertension and other famous academic journals, and owns 2 national inventions, 18 utility models and 72 software copyrights.
Lecture Outline:
Mapping techniques include multichannel electrical mapping (Electrical Mapping) and high-resolution fluorescence mapping (Optical Mapping) . Electrical Mapping uses multi-site recording electrodes to study the electrophysiological properties of the cell layer, isolated and in vivo heart, and is processed by software for excitation recognition, judgment and localization. Optical Mapping is a technique in which a fluorescent dye is loaded onto myocardial cells or tissues, and a high-speed camera records changes in fluorescence in response to changes in voltage or ion concentration in cardiac tissues, synchronizing action potentials with calcium signals.Mapping can be used to perform a variety of studies both at the level of the myocardial tissues and at the level of the whole heart, which contains the cardiac conduction system, and it can be a bridge between the cellular level of electrophysiology and the overall electrophysiological studies of the animal. Many topics start with Mapping, and then extend to the micro or macro level based on the results obtained by Mapping to study the electrophysiological characteristics of the heart in a comprehensive manner. This presentation will focus on the principles and functions of Mapping technology and case studies of Mapping technology in cardiac-related scientific research.
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